8/17/2023 0 Comments Capto q column"The extension of the Capto platform with Capto ImpRes ion exchangers demonstrates our commitment to supporting biopharmaceutical manufacturers with the most modern tools to improve their processes in terms of throughput, productivity, and economy," said Dr Nigel Darby, Vice President, Biotechnologies, GE Healthcare. The first Capto ImpRes products to be launched are Capto SP ImpRes and Capto Q ImpRes, strong cation and strong anion exchangers, respectively, that enable high throughput, high resolution polishing, and flexibility in process design.Ĭapto ImpRes media are based on a rigid high-flow agarose matrix that allows the use of high flow rates and higher bed heights, providing biopharmaceutical manufacturers with the possibility to reduce cycle times and maintain or reduce column equipment footprint, thus contributing to driving improvements in process economics. In addition, the potential for pre-packed columns to be gamma sterilized provides a compelling value proposition for companies looking to implement multi-column chromatography.Uppsala, Sweden – GE Healthcare, a unit of General Electric Company (NYSE: GE), announced today that the capabilities of the well-established Capto platform are now extended to include Capto ImpRes ion exchange chromatography media for late-stage purification of a wide range of biomolecules. Banks of multiple pre-packed columns can be delivered ready to run eliminating the need for multiple self-packed columns. This transfer of operational risk helps adopters of pre-packed columns to maintain leaner operations and focus on the most critical aspects of making and purifying therapeutic proteins.Īs the industry evolves to incorporate continuous processing, pre-packed columns are a perfect fit for multi-column chromatography. This allows a bioprocessing facility to outsource column packing, a non-value added step for making therapeutic proteins, and no longer worry about column packing issues. The ability of pre-packed column suppliers to focus their operations on column packing results in more consistently packed columns over time. Replacing traditional self-packed glass or stainless steel columns, pre-packed columns are packed by experts in state of the art facilities and are delivered ready to use for GMP processing. Operational flexibility for multi-product facilities.Rapid change over (no column packing, unpacking, or cleaning validation).In particular, adopters of pre-packed columns have realized the following benefits: Use of pre-packed columns in downstream chromatography has increased in response to the needs of multi-product facilities and initiatives focused on reducing change over time.
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